Figure 6
From: Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons
Artemin increased the mRNA of TRPA1 and TRPV1 in primary cultured DRG neurons. A: Artemin directly changed the gene expression of TRPV1 and TRPA1 in cultured DRG neurons using RT-PCR. B-D: Quantitative analysis showed a significant increase in mRNA levels of TRPV1 and TRPA1 after 18 hours of incubation with artemin (100 ng/ml), but not with GFRα3. (mean ± SEM, *p < 0.05, ***p < 0.001, compared with the vehicle group).