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Figure 1 | Molecular Pain

Figure 1

From: Paclitaxel induces acute pain via directly activating toll like receptor 4

Figure 1

Paclitaxel induces acute mechanical allodynia and reduces burrowing activities. (A) and (B): Mechanical thresholds of withdrawal responses in rats before (baseline) and at different time points after i.v. injection of paclitaxel at 2 mg/kg (A), 5 mg/kg (B), or vehicle are plotted. (C) and (D): Burrowing activities in rats at different time points after i.v. injection of paclitaxel at 2 mg/kg (C), 5 mg/kg (D), or vehicle are normalized to burrowing activities collected before the i.v. injection (baseline). Comparisons between baseline and at each time point are indicated with ^ for the paclitaxel group. Comparisons between the vehicle group and the paclitaxel group at each time point are labeled with #. One symbol: P < 0.05; Two symbols: P < 0.01; Three symbols: P < 0.001.

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