Table 1 Key brain regions that show significant changes in [ ¹⁴ C] signals using two different brain imaging methods

Infralimbic cortex (IL)

P = 1.00

P = 0.02*

P = 0.00*

Prelimbic cortex (PrL)

P = 1.00

P = 0.30

P = 0.00*

Cingulate cortex area 2 (Cg2)

P = 0.28

P = 0.60

P = 1.00

Cingulate cortex area 1 (Cg1-1)

P = 1.00

P = 0.41

P = 0.00*

Cingulate cortex area 1 (Cg1-2)

P = 0.02*

P = 0.04*

P = 0.36

Secondary motor cortex (M2-1)

P = 1.00

P = 1.00

P = 0.87

Secondary motor cortex (M2-2)

P = 0.28

P = 0.04*

P = 0.00*

Primary motor cortex (M1-1)

P = 1.00

P = 1.00

P = 0.86

Primary motor cortex (M1-2)

P = 0.58

P = 0.38

P = 0.88

Somatosensory cortex (S1-1)

P = 1.00

P = 0.93

P = 0.65

Somatosensory cortex (S1-2)

P = 0.53

P = 0.22

P = 0.98

Somatosensory cortex (S1-3)

P = 0.00*

P = 1.00

P = 1.00

Somatosensory cortex (S1-4)

P = 0.00*

P = 1.00

P = 1.00

Granular insular cortex (GI-1)

P = 1.00

P = 0.08

P = 0.34

Granular insular cortex (GI-2)

P = 0.82

P = 0.88

P = 0.85

Granular insular cortex (GI-3)

P = 0.00*

P = 1.00

P = 0.90

Agranular insular dorsal cortex (AID)

P = 1.00

P = 0.00*

P = 0.39

Agranular insular ventral cortex (AIV)

P = 1.00

P = 0.03*

P = 0.52

Striatum

P = 0.07

P = 1.00

P = 1.00

Hippocampus (Hippo-1)

P = 0.00*

P = 1.00

P = 1.00

Hippocampus (Hippo-2)

P = 0.00*

P = 1.00

P = 1.00

Hippocampus (Hippo-3)

P = 0.01*

P = 0.00*

P = 0.14

Mediodorsal thalamus nucleus (MD)

P = 0.00*

P = 0.54

P = 0.99

Ventral basal nucleus (VB)

P = 0.00*

P = 0.97

P = 0.00*

Ventrolateral thalamus nucleus (VL)

P = 0.00*

P = 1.00

P = 1.00

Ventromedial thalamus nucleus (VM)

P = 0.00*

P = 1.00

P = 1.00

Lateral hypothalamic area (LH)

P = 0.00*

P = 1.00

P = 1.00

Ventral medial hypothalamus nucleus (VMH)

P = 0.00*

P = 1.00

P = 1.00

Amygdala (Amygdala-1)

P = 0.00*

P = 1.00

P = 1.00

Amygdala (Amygdala-2)

P = 0.00*

P = 0.10

P = 0.01*

Periaqueductal gray (PAG)

P = 0.00*

P = 0.00*

P = 0.50