Figure 2From: Protease-activated receptors in the Achilles tendon–a potential explanation for the excessive pain signalling in tendinopathy Activation of protease-activated receptors. The protease-activated receptors are a family of G-coupled receptors which are activated through proteolytic cleaving (A) which unmasks a tethered ligand. This ligand then activates the receptor (B) which causes an intracellular signal to be transduced (C). Original art by Gustav Andersson.Back to article page