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Figure 8 | Molecular Pain

Figure 8

From: Protease-activated receptors in the Achilles tendon–a potential explanation for the excessive pain signalling in tendinopathy

Figure 8

Interaction of mast cell with tissues involved in tendinosis. Mast cells are recruited to the tendon tissue in cases of tendinosis, the mechanism behind which is unclear. A possible attractant is neuropeptides, such as SP (red dots), which can be produced by the tenocytes or released from peripheral nerve endings. These neuropeptides are also capable of causing the mast cells to degranulate, where upon tryptase and other proteases (blue dots) can affect the tendon, vessels and nerves via the protease-activated receptors. Original art by Gustav Andersson.

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Molecular Pain

ISSN: 1744-8069

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