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Figure 3 | Molecular Pain

Figure 3

From: Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex

Figure 3

Effect of TCC inhibitor on synaptic transmission of the ACC. A, Representative mEPSCs recorded in ACC neurons from Sham (black) and CCI (red) groups at a holding potential of −70 mV. Scale bars represent 20 pA and 1 sec. B, Comparison of frequency of mEPSCs between the Sham and CCI groups. **P < 0.01 compared to the Sham group. C, Comparison of amplitude of mEPSCs between the Sham and CCI groups. *P < 0.05 compared to the Sham group. D, Effect of NNC 55–0396 (20 μM) on frequency of mEPSCs. **P < 0.01 compared to the values before drug application. E, Effect of NNC 55–0396 on amplitude of mEPSCs. NS, not significant. F, Inhibition ratio of NNC 55–0396 on frequency of mEPSCs. G, Inhibition ratio of NNC 55–0396 on amplitude of mEPSCs.

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