Table 1 Effect of oral NAC (1.2 g) and placebo on nociceptive transmission in ten healthy volunteers
Placebo | NAC | Placebo | NAC | ||||||
|---|---|---|---|---|---|---|---|---|---|
Pre-drug | Post-drug | P | Pre-drug | Post-drug | P | Changes Pre-Post | Changes Pre-Post | P | |
N1-LEP (μV) | 7.1 ± 0.8 | 8.5 ± 0.6 | NS | 8.3 ± 1.4 | 4.8 ± 0.8 | <0.02 | 1.6 ± 0.8 | - 3.6 ± 3.8 | <0.02 |
N2P2-LEP (μV) | 30.9 ± 2.1 | 29.3 ± 2.1 | NS | 35.6 ± 3.7 | 21.8 ± 3.1 | <0.01 | -1.6 ± 1.9 | -13.9 ± 3.9 | <0.01 |
Laser pain (NRS 0-10) | 5.6 ± 0.2 | 5.5 ± 0.2 | NS | 6.3 ±0.5 | 5.3 ± 0.5 | <0.01 | 0.05 ± 0.6 | -1.0 ± 0.2 | <0.01 |
Cold detection threshold (°C) | 29.1 ± 0.4 | 28.7 ± 0.5 | NS | 28.8 ± 0.4 | 28.7 ± 0.6 | NS | -0.4 ± 0.4 | -0.1 ± 0.5 | NS |
Warm detection threshold (°C) | 34.8 ±0.5 | 35.9 ± 0.8 | NS | 34.2 ± 0.2 | 35.0 ± 0.4 | NS | 1.1 ± 0.8 | 0.8 ± 0.3 | NS |
Cold pain threshold (°C) | 13.8 ± 2.4 | 13.6 ± 2.3 | NS | 13.4 ± 2.5 | 14.8 ± 2.5 | NS | -0.2 ± 1.7 | 1.4 ± 1.7 | NS |
Heat pain threshold (°C) | 43.5 ± 0.7 | 43.7 ± 0.7 | NS | 43.8 ± 1.1 | 43.7 ± 1.1 | NS | 0.2 ± 0.5 | -0.1 ± 0.5 | NS |