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Table 1 Effect of oral NAC (1.2 g) and placebo on nociceptive transmission in ten healthy volunteers

From: N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

  Placebo NAC Placebo NAC  
  Pre-drug Post-drug P Pre-drug Post-drug P Changes Pre-Post Changes Pre-Post P
N1-LEP (μV) 7.1 ± 0.8 8.5 ± 0.6 NS 8.3 ± 1.4 4.8 ± 0.8 <0.02 1.6 ± 0.8 - 3.6 ± 3.8 <0.02
N2P2-LEP (μV) 30.9 ± 2.1 29.3 ± 2.1 NS 35.6 ± 3.7 21.8 ± 3.1 <0.01 -1.6 ± 1.9 -13.9 ± 3.9 <0.01
Laser pain (NRS 0-10) 5.6 ± 0.2 5.5 ± 0.2 NS 6.3 ±0.5 5.3 ± 0.5 <0.01 0.05 ± 0.6 -1.0 ± 0.2 <0.01
Cold detection threshold (°C) 29.1 ± 0.4 28.7 ± 0.5 NS 28.8 ± 0.4 28.7 ± 0.6 NS -0.4 ± 0.4 -0.1 ± 0.5 NS
Warm detection threshold (°C) 34.8 ±0.5 35.9 ± 0.8 NS 34.2 ± 0.2 35.0 ± 0.4 NS 1.1 ± 0.8 0.8 ± 0.3 NS
Cold pain threshold (°C) 13.8 ± 2.4 13.6 ± 2.3 NS 13.4 ± 2.5 14.8 ± 2.5 NS -0.2 ± 1.7 1.4 ± 1.7 NS
Heat pain threshold (°C) 43.5 ± 0.7 43.7 ± 0.7 NS 43.8 ± 1.1 43.7 ± 1.1 NS 0.2 ± 0.5 -0.1 ± 0.5 NS
  1. Values are means ± S.E.M.