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Figure 6 | Molecular Pain

Figure 6

From: The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury

Figure 6

ONO-4057 pretreatment affects peripheral inflammation and pCREB expression in the dorsal horn 20 min after intraplantar formalin injection. (A) Paw edema formation 1 h after formalin injection. (* p < 0.05, ONO-4057 (i.p. 0.25 mg) treated mice vs. vehicle (i.p.) treated mice, n = 5–6, unpaired Student’s t-test with Welch’s correction). (B) Quantification of Evans blue dye extravasation 1 h after formalin or vehicle injection. (** p < 0.01,*** p < 0.001, n = 6, Kruskal-Wallis with Dunn’s multiple comparison test). The number of phosphorylated CREB (pCREB)-positive neurons in the ipsilateral (C) and contralateral (D) dorsal horns of the spinal cord after intraplantar injections of formalin in mice pretreated with intraperitoneal ONO-4057 (0.25 mg, i.p.). (** p < 0.01, *** p < 0.001 vs. vehicle-pretreated mice, n = 4–5, unpaired Student’s t-test with Welch’s correction). Counts of pCREB-positive neurons in the ipsilateral (E) and contralateral (F) dorsal horn of the spinal cord after intraplantar formalin injection in mice pretreated with intraplantar ONO-4057 (2.35 μg, ipl.) injections. (* p < 0.05 vs. vehicle-pretreated mice, n = 5, unpaired Student’s t-test with Welch’s correction).

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