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Figure 3 | Molecular Pain

Figure 3

From: Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain

Figure 3

Effect of suramin and gossypetin on USP5-Cav3.2 interactions. (A) Cav3.2 immunoprecipitates incubated with different concentrations of suramin and probed for USP5 by Western blot. An actin loading control is shown. (B) Quantification of USP5 bound to Cav3.2 immunoprecipitates by densitometry. (C) Cav3.2 immunoprecipitates incubated with different concentrations of gossypetin and probed for USP5 by Western blot. An actin loading control is shown. (D) Quantification of USP5 bound to Cav3.2 immunoprecipitates by densitometry. (E) Cav3.2 immunoprecipitates incubated with vehicle (DMSO, lane 1), 50 μM suramin (lane 2) and 50 μM oxytetracycline (lane 3).

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