Figure 4

Antihyperalgesic effect of compounds in a model of neuropathic pain. Time course of the antihyperalgesic effect of intrathecally (i.t.) delivered suramin (10.0 μg/i.t.) or gossypetin (10.0 μg/i.t.) on mechanical hyperalgesia of mice subjected to nerve injury two weeks prior to the experiment. Each circle represents the mean ± S.E.M. (n=6-7) and is representative of 2 independent sets of experiments. Statistical analyses were performed by two-way ANOVA followed by a Tukey’s test. The dashed line and number symbol indicate the range of data points where injured animals differed from the sham group (P<0.001).