Figure 6

Effect of compounds on hyperalgesia of Cav3.2 null mice. (A) Blind-analyses of the time course of mechanical hyperalgesia of CFA injected Cav3.2 null and WT mice treated with gossypetin (10.0 μg/i.t.). (B) Data for mechanical hyperalgesia of Cav3.2 null and WT mice when measured 15 minutes after treatment with gossypetin. (C) Mechanical hyperalgesia of CFA injected Cav3.2 null and WT mice treated with suramin (10.0 μg/i.t.). (D) Data for mechanical hyperalgesia of Cav3.2 null and WT mice when measured 15 minutes after treatment with suramin. Each circle/bar represents the mean ± S.E.M. (n=6-7) and data are representative of 2 independent sets of experiments. Statistical analyses were performed by two-way ANOVA followed by Tukey’s test. The dashed line and hashtag indicate the range of data points where injured animals differed from the sham treated group (P<0.001). Ns: non-significant.