Figure 7
Effects of suramin on acute visceral pain. (A) Analyses of writhing responses of intrathecally treated mice with suramin (0.1-10.0 μg/i.t.)1 hour prior to acetic acid injections. (B). Effect on intraperitoneally delivered suramin (0.3-30 mg/kg, 1 hour prior ) on writhing responses induced by acetic acid. Each circle represents the mean ± S.E.M. (n=8-10) and is representative of 2 independent sets of experiments. Statistical analyses were performed by two-way ANOVA followed by a Tukey’s test. The dashed line and number symbol indicate the range of data points where diabetic neuropathic animals differed from the non-diabetic group (P<0.001).