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Figure 7 | Molecular Pain

Figure 7

From: Sensitization of P2X3 receptors by cystathionine β-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation

Figure 7

Antagonism of hindpaw injection of CBS inhibitor on LDH-induced pain hypersensitivity. (A) A single hindpaw injection of the CBS inhibitor AOAA at different doses (3, 6 and 9 mg/kg body weight) did not significantly alter mechanical allodynia induced by LDH. (B) A single hindpaw injection of the CBS inhibitor AOAA did not alter the body weight bearing difference induced by LDH. (C) Chronic effects of AOAA injection (9 mg/kg body weight, once every day for 7 consecutive days) did not altered mechanical withdrawal threshold. (D) Multiple injections of AOAA did not alter the body weight bearing difference. (E) Multiple hindpaw injections of AOAA did not affect protein levels of P2X3 receptor of LDH rats (n = 4 for each group).

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