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Figure 1 | Molecular Pain

Figure 1

From: Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain

Figure 1

ZBD-2 reduces anxiety-like behaviors. (A) Chemical structures of ZBD-2. (B) EPM test were performed on Day 21 after CFA injection. ZBD-2 (0.15 and 1.5 mg/kg) reversed the time in the open arms in CFA-injected mice. (C) ZBD-2 (0.15 and 1.5 mg/kg) reversed the open arm entries in CFA-injected mice. (D) No difference of the total number of arm entries in each group. (E) In OF test, ZBD-2 (0.15 and 1.5 mg/kg) reversed the time in center areas in CFA-injected mice. (F) No difference of the total distance traveled in each group. n = 6 in each group, *p < 0.05, **p < 0.01 compared to the control group; # p < 0.05, ## p < 0.01 compared to the CFA+ saline group.

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Molecular Pain

ISSN: 1744-8069

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