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Figure 1 | Molecular Pain

Figure 1

From: Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons

Figure 1

Selection of cells for detailed analysis. A. Left panel shows the activation protocol, applied in voltage clamp from a holding potential of −60 mV. A pre-pulse to −100 mV (100 ms duration) was followed by a series of depolarising steps (5 mV increments, 50 ms duration, −100 to +20 mV). Grey shaded area indicates the time period (~5 s) over which the right traces were captured for analysis. Centre and left panels show representative traces from poorly- and adequately clamped adult SDH neurons. Capacitive currents have been removed for clarity (asterisk). B. Current–voltage (I-V) plots for the recordings shown in A. Arrow in left plot indicates the deflection that characterizes poorly clamped currents (eg, centre panel of A, arrows). C. Group data showing I-V plots generated from adequately clamped currents in neonatal (open circles) and adult SDH neurons (filled circles). Data for each cell have been normalized to peak current and plotted against membrane potential. Sodium currents in neonates function over a narrower membrane potential range than those from adults. D. Relative conductance plotted as a function of voltage for neonates (open circles) and adult SDH neurons (filled circles).

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