Figure 5
From: Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons
TTX sensitivity of sodium currents from neonatal and adult SDH neurons. A. Upper trace shows protocol (repeated 0.5 Hz) applied to neonatal and adult SDH neurons during bath application of 1 μM TTX. Bottom trace shows representative maximum sodium current recorded in an adult SDH neuron (black trace) before and after application of 1 μM TTX for 2 mins (grey trace). Both traces were recorded during the onset of the depolarising step (grey shading in top panel). B. Plots of peak normalized current versus time during application of 1 μM TTX. Sigmoid curves show the onset of TTX block was more rapid in neonates (* p < 0.05), however, the slope of the relationship was similar in neonatal and adult recordings.