The role of MeCP2 in pain suppression. In WT mice, hindpaws after SNI showed significant reduction in withdrawal threshold compared to contralateral hindpaws in mechanical von Frey test. But MeCP2 overexpression mice only had a slight downgrade in paw withdrawal threshold and their withdrawal threshold after SNI shows no diffierence compared with WT contralateral. 9 mice were tested in each group. All values are represented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.