Figure 4

Alleviation of VZV-induced hypersensitive nocifensive behaviors by administration of TNFα soluble receptor (sTNFR) expressed from an HSV vector. All animals (n = 4) were infected with VZV at day-0. At 21 days post VZV infection (denoted by arrowheads), animals were inoculated with either sTNFR vector (TNFasR) or control vector (T0ZHG). Animals were monitored for hypersensitivity to (top panel) mechanical (gram weight) and (bottom panel) thermal sensitivity (ratio of ipsilateral/contralateral paw withdrawal latencies) and the data is plotted as Mean + SEM. Each time-point was compared by two-tailed T-test (* = p < 0.05). Mean area under the curve was calculated for the region represented by brackets for each animal and compared by two-tailed T-test (* = p < 0.05, ** = p < 0.01) with the Mean ± SEM plotted.