Skip to main content

Table 1 Summary of characteristics of vital vectors used for pain analgesia and morphine tolerance/dependence

From: Current gene therapy using viral vectors for chronic pain

  AD AAV LV HSV
Wild-type DS-DNA SS-DNA SS-RNA DS-DNA
Genome size 36 kb 4.7 kb 9.2 kb 152 kb
Capacity of gene insert ~7.5 kb ~4.5 kb ~8 kb ~40 kb
Persistence of gene expression days-weeks months-years months-years days-years
Inoculation IT IT IT, nerve SC paw, PAG, bladder wall
Gene product IL-10 IL-10 TNF shRNA, IL-10 IL-4, IL-10, TNFSR
Pain models NP IP NP NP, IP
M-T/M-W M-T    M-T, M-W
  1. DS-DNA, double strain DNA; SS-DNA, single strain DNA; SS-RNA, single strain RNA; IT, intrathecal; SC, subcutaneous injection; NP, neuropathic pain; IP, inflammatory pain; M-T, morphine tolerance; M-W, morphine withdrawal.