Current gene therapy using viral vectors for chronic pain

Molecular Pain

Table 1 Summary of characteristics of vital vectors used for pain analgesia and morphine tolerance/dependence

	AD	AAV	LV	HSV
Wild-type	DS-DNA	SS-DNA	SS-RNA	DS-DNA
Genome size	36 kb	4.7 kb	9.2 kb	152 kb
Capacity of gene insert	~7.5 kb	~4.5 kb	~8 kb	~40 kb
Persistence of gene expression	days-weeks	months-years	months-years	days-years
Inoculation	IT	IT	IT, nerve	SC paw, PAG, bladder wall
Gene product	IL-10	IL-10	TNF shRNA, IL-10	IL-4, IL-10, TNFSR
Pain models	NP	IP	NP	NP, IP
M-T/M-W	M-T			M-T, M-W

DS-DNA, double strain DNA; SS-DNA, single strain DNA; SS-RNA, single strain RNA; IT, intrathecal; SC, subcutaneous injection; NP, neuropathic pain; IP, inflammatory pain; M-T, morphine tolerance; M-W, morphine withdrawal.

ISSN: 1744-8069