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Table 2 Select neurochemical markers of the cornea, adapted from Shaheen et al., 2014 [24]

From: Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders

Nerve fiber type

Associated markers

Somatosensory (mechanical)

NF-200

Somatosensory (nociceptive)

 

  Peptidergic

CGRP

SP

PACAP

Galanin

  Non-peptidergic

FRAP

Autonomic

 

  Sympathetic

NE

5-HT

NPY

  Parasympathetic

Ach

VIP

NPY

Galanin

  1. NF-200 = neurofilament-200 kDa, CGRP = calcitonin gene-related peptide, SP = substance P, PACAP = pituitary adenylate cyclase activating peptide, FRAP = fluoride-resistant acid phosphatase, NE = norepinephrine, 5-HT = serotonin, NPY = neuropeptide Y, Ach = acetylcholine, VIP = vasoactive intestinal peptide.