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Table 4 Prevention of chronic post-operative pain with perioperative gabapentin and pregabalin: randomized, placebo-controlled studies

From: Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders

Study Surgery Metric of pain assessment Treatment Outcome
Fassoulaki 2005 [86] Breast surgery for cancer Presence of pain (yes vs no) Gabapentin (400 mg q6h, started 12 h pre-op, continued to POD 8, local anesthetic cream, and ropivacaine in wound (n = 25) vs placebo (n = 25) Non-significant trend to less pain (30% vs 57%) and anesthetic use (0% vs 19%) at 6 months
Buvanendran 2010 [87] Total knee arthroplasty Neuropathic pain via Leeds Assessment of Neuropathic Symptoms and Signs scale Pregabalin (300 mg) (n = 113) vs placebo (n = 115) Significantly reduced pain in pregabalin group (0% at 3 & 6 months) vs placebo (8.7% and 5.2% at 3 & 6 mo).
Sen 2009 [88] Elective hysterectomy Verbal rating scale scores Gabapentin 1.2 g w/placebo infusion (n = 20); ketamine w/oral placebo (n = 20); Control group (n = 20) Significantly reduced pain scores in gabapentin group vs ketamine & placebo at 6 months