Figure 2From: In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal hornActions of AITC on inhibitory synaptic transmission in SG neurons. (A) Continuous chart recording of IPSCs before and during the action of AITC (300 μM; top). Three consecutive traces of IPSCs are shown in an expanded scale of time, before (bottom left) and under the action of AITC (bottom right). The holding potential (VH) used was −0 mV. (B) Cumulative distribution of the inter-event interval (left) and amplitude (right) of IPSCs in the control (dotted line) and during (continuous line) the action of AITC. AITC shifted the inter-event interval and amplitude to a shorter and a larger one (same neuron as in Figure 2A). (C) Summary of IPSC frequency (left) and amplitude (right) under the action of AITC (n = 9) relative to control. (D) The frequency of IPSCs following application of AITC plotted against time. Each bar indicates data calculated from IPSCs measured for 30 s (same neuron as in Figure 2A). “Duration” represents the period when frequency increases more than 20% of the control. (E) Summary of average duration of IPSCs and EPSCs evoked by AITC (n = 5). *P < 0.05.Back to article page