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Figure 5 | Molecular Pain

Figure 5

From: In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn

Figure 5

Changes in membrane potential produced by TRPA1 activation in SG neurons. (A) A continuous current-clamp recording of the membrane potential showing that AITC (300 μM) evokes hyperpolarization. (B) A continuous current-clamp recording of the membrane potential showing that AITC (300 μM) evokes depolarization in the presence of TTX. (C) Membrane potential of SG neurons under the action of AITC (n = 5) relative to control (left). Membrane potential of SG neurons under the action of AITC in the presence of TTX (n = 5) relative to control (right). *P < 0.05.

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