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Figure 5 | Molecular Pain

Figure 5

From: Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons

Figure 5

Desensitization of TRPA1 by polysulfide in mouse DRG neurons. (A) (a) Actual recording of [Ca2+]i responses to Na2S3 (10 μM) twice with an interval of 15 min and then allylisothiocyanate (AITC, 0.3 mM), and KCl (K, 80 mM), and (b) those to AITC (0.3 mM) twice with an interval of 15 min and then Na2S3 (10 μM), and KCl (80 mM). (B) Open and filled columns show the increases of [Ca2+]i responses to Na2S3 (a) and AITC (b) in the first stimulation (Naïve), and those in the second stimulation after each chemical, respectively. Columns with vertical lines show mean ± SEM (Ba; n = 25, Bb; n = 54). **P, < 0.01 vs. Naive.

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