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Figure 8 | Molecular Pain

Figure 8

From: Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons

Figure 8

Intraplantar administration of polysulfide produces pain-related behavior in mice. (A) Changes in number of pain-related behaviors (a; Licking, b; Lifting) of wild-type and TRPA1(−/−) mice after intraplantarly injection of Na2S3 (500 nmol/paw) and summarized number of behaviors during 10 min after Na2S3 injection. (B) Left and right panel show that changes in paw thickness of wild-type and TRPA1(−/−) mice before and after intraplantarly injection of Na2S3 (left), and changes in paw thickness 30 min after injection of Na2S3 or HEPES-buffered solution (Vehicle), respectively. Symbols and columns with vertical lines show mean ± SEM (A: Wild-type; n = 5, TRPA1(−/−); n = 4, TRPV1(−/−); n = 4, B: Wild-type; n = 4, TRPA1(−/−); n = 4, TRPV1(−/−); n = 4). *P, < 0.05, **P, <0.01, vs. Wild type.

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