Skip to main content
Fig. 1 | Molecular Pain

Fig. 1

From: Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Fig. 1

Depletion of dopaminergic neurons both in the striatum and substantia nigra (SN) induced by MPTP injection in mice. a A representative western blot image using a tyrosine hydroxylase (TH) antibody. b Quantification of normalized TH expression levels in the striatum and the substantia nigra pars compacta (SNpc) (n = 5 per group, p < 0.0001, striatum; p < 0.0005, SNpc, unpaired Student’s t-test). c Visualization of loss of dopaminergic neurons by TH immunostaining in the striatum. d Quantification of reduction of striatal fibers in MPTP-treated mice assessed by TH immunostained optical density (n = 3 per group, p < 0.05, dorsomedial (DM) or dorsal striatum (SUM), unpaired Student’s t-test; p < 0.05, dorsolateral versus dorsomedial striatum in saline-treated mice, paired Student’s t-test; p < 0.005, dorsolateral versus dorsomedial striatum in MPTP-treated mice, paired Student’s t-test). e Visualization of loss of dopaminergic neurons by TH staining in the SNpc. f Quantification of reduction of SNpc dopaminergic neurons in MPTP-treated mice (n = 3 per group, p < 0.05, unpaired Student’s t-test). DM, Dorsomedial striatum; DL, Dorsolateral striatum

Back to article page