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Fig. 6 | Molecular Pain

Fig. 6

From: Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Fig. 6

Change of neurons in the spinal cord of MPTP-administered mice. a Comparison of MAP2-immunopositive spinal neurons in the dorsal and ventral horn of the lumbosacral spinal cord between saline- and MPTP-treated mice (scale bars = 200 μm). Upper and lower rectangles represent dorsal and ventral horns, respectively. Higher magnification images of these dorsal and ventral horns showed in lower two panels (scale bars = 200 μm). b MPTP-treated PD model mice did not exhibit any neuronal changes in either the dorsal or ventral horn of the lumbosacral spinal cord (n = 4 per group, unpaired t-test). c Comparison of c-Fos immunolabelled neurons in the dorsal and ventral horn of lumbar spinal cord between saline- and MPTP-treated mice (scale bars = 200 μm). Higher magnification images of these dorsal and ventral horns showed in lower two panels, respectively (scale bars = 200 m). d and (e) MPTP-treated PD model mice did not show any differences in neuronal activity in either the dorsal or ventral horn of the lumbar spinal cord (n = 4 per group, unpaired t-test), respectively

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Molecular Pain

ISSN: 1744-8069

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