Upregulation of T-type Ca2+ channels in long-term diabetes determines increased excitability of a specific type of capsaicin-insensitive DRG neurons

Table 1 Blood glucose level and body weight of experimental rats

Group	Old rats, T-current measurements^a		Old rats, Na-current measurements^b		2-3 months old rats^c
	Control	Diabetic 9-13 weeks	Control	Diabetic 9-13 weeks	Control	Diabetic 6-7 weeks
	Control	Diabetic 9-13 weeks	Control	Diabetic 9-13 weeks	Control	Hypoalgesic	Hyperalgesic
Body weight, g	325 + 25	212 + 20^d	323 + 12	213 + 14^d	153 + 4	128 + 11^e	125 + 8^e
Blood glucose level, mM	4.5 + 0.3	27 + 2^f	4.4 + 0.2	28 + 2^f	4.3 + 0.3	27 + 2^g	26 + 2^g
n	4	4	3	3	3	3	3

^aAnimals (8 months old) were used to measure T-type current and excitability parameters
^bAnimals (8 months old) were used to measure Na⁺ current
^cAnimals were used to measure T-type current
^dANOVA one way test, p < 0.01
^eThere was no significant difference between the group of diabetic hypoalgesic or hyperalgesic and control rats (p > 0.08, ANOVA one way test)
^fStudent’s t-test: p < 0.001 for each control and corresponding diabetic group
^gStudent’s t-test with α level adjusted with Bonferroni’s procedure: p < 0.005 when diabetic hypoalgesic and hyperalgesic groups were compared with the same control group

ISSN: 1744-8069