Figure 10

Effects of administration of Tat-3A or Tat-3Y on DPI-induced anxiety behaviors in the EPM 7 days after surgery. a Computer-generated exploration paths of representative mice in the EPM test subjected to the following conditions: sham control, DPI plus Tat-3A administration, DPI plus Tat-3Y administration. Open, open arms (dashed line, grey); closed, closed arms (black). b, c The bar summary shows the number of entries (b) and the time spent (c) in the open arm. d, e The bar summary shows the number of unprotected (d) and protected (e) head dips during the EPM test. All values are expressed as mean ± SEM. n = 7–10 mice for each group shown in the figure. *P < 0.05, **P < 0.01, sham vs. DPI + Tat-3A, unpaired Student’s t test. ^# P < 0.05, DPI + Tat-3A vs. DPI + Tat-3Y as indicated, unpaired Student’s t test.