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Figure 9 | Molecular Pain

Figure 9

From: Temporal dynamics of anxiety phenotypes in a dental pulp injury model

Figure 9

Effects of administration of ibuprofen or ProTx-II on DPI-induced anxiety behaviors in the EPM 7 days after surgery. a Computer-generated exploration paths of representative mice in the EPM test subjected to the following conditions: sham control, DPI, DPI plus ibuprofen administration, DPI plus ProTx-II administration. Open, open arms (dashed line, grey); closed, closed arms (black). b, c The bar summary shows the number of entries (b) and the time spent (c) in the open arm. d, e The bar summary shows the number of unprotected (d) and protected (e) head dips during the EPM test. All values are expressed as mean ± SEM. n = 5–10 mice for each group shown in the figure. *P < 0.05, **P < 0.01, ***P < 0.01, sham vs. DPI, unpaired Student’s t test. # P < 0.05, DPI vs. DPI + ibuprofen or DPI vs. DPI + ProTx-II as indicated, unpaired Student’s t test.

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