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Figure 4 | Molecular Pain

Figure 4

From: PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias

Figure 4

Intrathecal delivery of a GSK-3β activator (LY294002, LY; selective PI3K inhibitor) reduces DRG neurite outgrowth 3 days after QUIS-induced SCI. a QUIS-injection (QUIS veh) resulted in robust neurite outgrowth 3 days after injury compared to sham veh treated. Animals that received LY94002 following injury (QUIS LY) show growth responses similar to controls (sham veh). b Quantification of % of neurons with neurites. c Average length of longest neurite. d Mean length of small, medium, and large neurites. Number of animals per group: sham vehicle (veh) n = 5, QUIS (veh) n = 5, QUIS (LY) n = 4. Data are represented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar 25 μm.

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Molecular Pain

ISSN: 1744-8069

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