Figure 10
From: Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats
Intrathecal administration of the CaCCs inhibitors did not affect the motor coordination of neuropathic rats. Time-course of the effect of NFA (300 μg), T16Ainh-A01 (10 μg) or CaCCinh-A01 (10 μg) on motor coordination of rats subjected to L5/L6 spinal nerve ligation compared to naïve, sham and vehicle groups. Rats were assessed on the Rotarod apparatus before and at 0, 1.5 and 3 h after drug administration (n = 6). Data are expressed as the latency to fall off the Rotarod apparatus determined by the mean of three trials for each rat at each time. Note that drugs did not modify motor coordination at any time.