Figure 2
From: Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats
Intrathecal injection of selective CaCCs inhibitors reduces tactile allodynia. Time-course of the antiallodynic effect of T16Ainh-A01 (10 μg, a) and CaCCinh-A01 (10 μg, c) in rats subjected to L5/L6 spinal nerve injury. Withdrawal threshold was assessed 14 days after spinal nerve injury. Dose–response relationship of the antiallodynic effect of T16Ainh-A01 (0.01–10 μg, b) and CaCCinh-A01 (0.01–10 μg, d) in spinal nerve injured rats compared to sham (S) and vehicle (V) groups. Data are presented as the mean ± SEM for six animals. Note that selective CaCCs inhibitors significantly increased withdrawal threshold as well as the % of maximum possible effect (%MPE). *Significantly different from the vehicle group (p < 0.05), as determined by one-way ANOVA followed by the Student–Newman–Keuls test.