Illustration of the preparation and the compound action potential (CAP). a
Left panel the L5 ganglion attached to dorsal root (DR) and spinal nerve was removed of naïve, sham and neuropathic rats. Right panel the tissue was collocated into a recording chamber. The spinal nerve was stimulated at 50xT to evoke maximal C fiber CAP recorded in the dorsal root. b
Upper panel examples of maximal C fiber CAP recorded extracellularly from naïve (black trace), sham and neuropathic (red trace) rats. The bar chart in the lower panel shows the comparison of CAP. Note that the size of the CAP in neuropathic was higher than in naïve rats.