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Figure 9 | Molecular Pain

Figure 9

From: Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats

Figure 9

Effect of CaCCs inhibitors on the CAP of naïve and neuropathic rats. Upper panels examples of the CAP recorded in absence (control, black trace) and in presence of T16Ainh-A01 [20 μM] (red trace) recorded from naïve (a) and neuropathic (c) rats. The bar charts below of traces show the comparison of normalized area under the C component of the CAP between the naïve and T16Ainh-A01 groups. Note that T16Ainh-A01 diminished the compound action potential in neuropathic, but not in naïve, rats. Lower panels examples of CAP recorded in absence (control, black trace) and in presence of CaCCinh-A01 [20 μM] (red traces) recorded from naïve (b) and neuropathic (d) rats. The bar charts below of traces compare the normalized area under the C component of the CAP between the control and CaCCinh-A01 groups. Note that CaCCinh-A01 decreased the CAP size in neuropathic, but not in naïve, rats. *Significantly different from the neuropathic group (p < 0.05), as determined by the Student t test.

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