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Figure 2 | Molecular Pain

Figure 2

From: Function and postnatal changes of dural afferent fibers expressing TRPM8 channels

Figure 2

Postnatal reduction of the EGFP-positive fiber density in the dura of TRPM8 EGFPf/+ mice. a Representative images of axons containing EGFP-ir in TRPM8 EGFPf/+ dura and CGRP-ir in wild-type dura from P2, P21 and adult mice. b Average EGFP-expressing and CGRP-expressing axon densities in the dura mater of TRPM8 EGFPf/+ (n = 6–10 mice in each group) and wild-type mice (n = 4–10 mice in each group) between P2 and adulthood, respectively. Within the EGFP groups: one-way ANOVA overall significance p < 0.001, ***p < 0.001, post hoc Bonferroni test compared with the P2 group; ## p < 0.01, ### p < 0.001, post hoc Bonferroni test compared with the P16 group. Between EGFP and CGRP groups: two-way ANOVA overall significance p < 0.001, † p < 0.05, †† p < 0.01, post hoc Bonferroni test between the corresponding EGFP and CGRP groups. c EGFP-positive axon densities in midline and lateral regions of dura mater of P2 and adult TRPM8 EGFPf/+ mice (n = 10 and 6 mice, respectively). **p < 0.01, ***p < 0.001, two-way ANOVA with post hoc Bonferroni test, compared with the corresponding P2 groups.

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