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Figure 11 | Molecular Pain

Figure 11

From: G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy

Figure 11

Axonal transport of GIRK2-LI. A GIRK2-LI is observed in many PGP9.5+ fibers in intact sciatic nerve. B After a 10-h nerve ligation, a strong accumulation of GIRK2-LI is seen on both proximal and distal side (arrowheads). C A few GIRK2+ and PGP9.5+ fibers (arrowheads) are observed in the epidermis layer of glabrous skin in rat hind paw. D Twenty-one days after unilateral lumbar dorsal rhizotomy, a reduction of GIRK2-LI is seen within region 2 (arrowheads), but not in region 1 (arrows), as compared with the contralateral side. A strong reduction of CGRP-LI is seen ipsilaterally. Scale bars indicate 500 μm (B), 200 μm (A, C, low magnification; D), 50 μm (C, high magnification).

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Molecular Pain

ISSN: 1744-8069

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