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Figure 9 | Molecular Pain

Figure 9

From: G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy

Figure 9

Protein and mRNA expression of GIRK2 in DRGs and spinal cord 14 days after axotomy. A, B Percentages of GIRK2+ NPs is significantly decreased in the ipsilateral (n = 8) as compared to the contralateral DRGs (n = 8). C Western blot result showing GIRK2 protein levels confirms this effect (n = 4 per group). D GIRK2 mRNA shows a modest signal in the contralateral DRG, and is down-regulated in the ipsilateral DRG after axotomy (upper panel: low magnification; lower panel: high magnification). E GIRK2-LI (within white frame) in the dorsal horn. F Monitoring fluorescence intensity in the dorsal horn shows down-regulation of GIRK2-LI in all animals (n = 3 per group). **P < 0.01. Scale bars indicate 200 μm (D, upper panel; A and E), 100 μm (D, lower panel).

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Molecular Pain

ISSN: 1744-8069

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