Fig. 3

Suppression by retigabine of cold-induced action potential firing in nociceptive cold-sensing trigeminal neurons. a Sample traces show an example of cold-evoked action potential firing in a nociceptive cold-sensing TG neuron in the absence (control) and presence of 10 µM retigabine. Recordings were made under the whole-cell current-clamp mode. Cooling temperature ramp was applied from 24 to 8°C as indicated under the recording traces. b Summary data shows significant reduction of cold-evoked action potential firing in nociceptive cold-sensitive TG neurons (n = 8). Action potential numbers are normalized to control value. Data represent Mean ± SEM, **P < 0.01.