KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia

Table 1 M-currents, resting membrane potentials and rheobase of cold-sensing TG neurons

	AP type	M-current amplitude (pA)			RMP (mV)			Rheobase (pA)
	AP type	All cells	Cntl	+Lino	All cells	Cntl	+Lino	All cells	Cntl	+Lino
NoCTG	Slow with hump	134 ± 24^###, n = 15	174 ± 32, n = 9	82 ± 17**, n = 9	−66 ± 1^#, n = 15	−67 ± 2, n = 8	−60 ± 2**, n = 8	426 ± 105^###, n = 15	660 ± 164, n = 7	381 ± 96*, n = 7
NnCTG	Fast no hump	47 ± 9, n = 21	41 ± 10, n = 17	18 ± 6***, n = 17	−62 ± 1, n = 21	−62 ± 1, n = 17	−58 ± 2***, n = 17	92 ± 17, n = 21	101 ± 22, n = 17	87 ± 21^ns, n = 17

Data represent Mean ± SEM.
NoCTG nociceptive cold-sensing trigeminal ganglion neurons, NnCTG non-nociceptive cold-sensing trigeminal ganglion neurons, AP action potential, RMP resting membrane potential, Cntl control without linopirdine, +Lino in the present of 20 µM linopirdine.
* P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significant difference control vs +Lino, paired Student’s t test; ^# P < 0.05, ^### P < 0.01, NoCTG group vs NnCTG group, unpaired Student’s t test.

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