Fig. 1From: Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitorsThermal antinociceptive effects of morphine under the UCMS condition. The effects of morphine on thermal nociceptive latency (a) and %MPE (b) in a hot-plate test under the UCMS (closed circles n = 15) and non-stress (open circles n = 13) conditions. Intraperitoneal morphine was repetitively administered to the mice at doses of 1, 2, and 7 mg/kg, for cumulative doses of 1, 3, and 10 mg/kg, respectively. ## p < 0.01, # p < 0.05, significantly differed from the non-stress condition. Data are expressed as mean ± SEM.Back to article page