Fig. 2From: Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitorsThermal antinociceptive effects of tramadol under the UCMS condition. The effects of tramadol on thermal nociceptive latency (a) and %MPE (b) in a hot-plate test under the UCMS (closed circles n = 8) and non-stress (open circles n = 8) conditions. Intraperitoneal tramadol was repetitively administered to the mice at doses of 10, 20, and 70 mg/kg, for cumulative doses of 10, 30, and 100 mg/kg, respectively. Data are expressed as mean ± SEM.Back to article page