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Table 1 Procedures and schedule of UCMS

From: Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors

 

Stressor

Duration (h)

Day of application

1

Cage tilting (45°)

14

1, 9, 17, 27

2

Damp bedding

24

2, 14, 21, 30, 34

3

Food deprivation

24

3, 15, 20, 28, 33

4

Food and water deprivation

14

6, 12, 24

5

Lights on overnight

24

4, 19, 25, 32

6

Small cage

24

7, 18, 29, 35

7

Cage mate shuffle

24

5, 13, 31

8

Lights off during the day

24

8, 16, 22

9

Cage exchange

24

10, 23

10

Non stress

 

11, 26