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Fig. 7 | Molecular Pain

Fig. 7

From: p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats

Fig. 7

Schematic presentation of contribution of p38 phosphorylation in medullary microglia to ectopic orofacial inflammatory pain. Microglia in medulla and upper cervical spinal cord was activated following trapezius muscle inflammation. IL-1β release from the activated microglia in trigeminal spinal subnucleus caudalis (Vc) was accelerated through p38 phosphorylation and the excitability of wide dynamic range (WDR) neurons in Vc was enhanced via IL-1β signaling. The enhancement of excitability of WDR neurons in Vc after trapezius muscle inflammation may result in ectopic mechanical allodynia in orofacial region.

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