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Fig. 1 | Molecular Pain

Fig. 1

From: Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain

Fig. 1

Inhibitory effects of systemically applied riluzole on vocalizations. a, b Riluzole (8 mg/kg, i.p.) had no effect on audible vocalizations (a) but inhibited ultrasonic vocalizations (b) to noxious stimulation of the knee joint compared to vehicle in normal naïve rats (n = 6). n.s. non-significant; *P < 0.05; paired t test. c, d Induction of arthritis resulted in a significant increase of audible (c) and ultrasonic (d) vocalizations evoked by noxious stimuli. Riluzole (8 mg/kg, i.p.; n = 19 rats) inhibited vocalizations of arthritic rats compared to predrug and vehicle (HBC, 30 %, i.p.; n = 16 rats). n.s. non-significant; *,**,***P < 0.05, 0.01, 0.001; repeated measures one-way ANOVA (compared to predrug) and unpaired t test (compared to vehicle) with Bonferroni posttests/correction. Bar histograms show mean ± SEM

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Molecular Pain

ISSN: 1744-8069

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