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Fig. 1 | Molecular Pain

Fig. 1

From: Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms

Fig. 1

Characterization of the brain endocannabinoid system in FABP5/7 KO mice. a RT-PCR analysis of FABP expression in brains of WT and FABP5/7 KO mice. Note that of the ten FABP isoform profiled, selective deletion of FABP5 and FABP7 was observed in the brains of FABP5/7 KO mice. b Western blot confirms the absence of FABP5 and FABP7 in the brains of FABP5/7 KO mice. c Brain PEA, OEA, AEA, and 2-AG levels in WT and FABP5/7 KO mice. *p < 0.05; **p < 0.01; ***p < 0.001 (n = 6). d Hydrolysis of AEA in brain homogenates of WT and FABP5/7 KO mice. e Representative western blots of brain FAAH, MAGL, COX-2, NAPE-PLD, and CB1 expression in WT and FABP5/7 KO mice. f Quantification of western blots expressed as a ratio of fold change between FABP5/7 KO and WT mice

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Molecular Pain

ISSN: 1744-8069

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