Fig. 4
From: Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy
Partial sciatic nerve ligation induces persistent glycolytic dysfunction in injured nerves. a The proportion of the extracellular acidification rate specific to glycolysis is persistently reduced following partial sciatic nerve ligation. This demonstrates that the ability of the nerve to increase glycolytic activity in response to bioenergic stress is reduced following nerve injury. b Glycolytic capacity is also persistently reduced following partial sciatic nerve ligation. A reduction in glycolytic capacity suggests injured nerve tissue is less capable of producing ATP by glycolytic mechanisms