Fig. 5
From: Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy
Nerve injury does not affect non-mitochondrial respiration, but increases non-glycolytic acidification. a Nerve injury induces no proportionate change in non-mitochondrial respiration. This suggests that oxygen consumption of non-mitochondrial processes such as cellular oxidases do not undergo alterations following nerve injury. b Nerve injury induces a persistent increase in non-glycolytic acidification. This suggests that non-glycolytic processes which produce acids are increased following nerve injury. Increased acidification may have undesirable effects on sensory neuron excitability