Fig. 2

ACC ultrastructure as observed by transmission electron microscopy. a In Sham group, Gray’s type I synapses (arrows) were identified in the ACC region with regular structures. b SNI changed the synaptic ultrastructure in ACC. After SNI, the mitochondria within anterior region of synapse became swollen and increased in number (asterisks), the thickness of postsynaptic density was thickened, and the intersynaptic space was decreased, even close to disappearing (arrows). The structure of synapses (arrows) in SNI + Lenti-Cdh1 group (c), but not in SNI + Lenti-control group (d), was significantly improved compared with SNI group. Compared with the SNI group, in the ACC, the level of postsynaptic density thickening was reduced significantly, and synaptic cleft was identifiable (c arrows). Scale bar 1 μm