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Fig. 4 | Molecular Pain

Fig. 4

From: Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury

Fig. 4

The effects of LTB4 on NMDA receptor-mediated sEPSCs. a NMDA receptor-mediated sEPSC has a reversed waveform with slow decay at a holding potential of +40 mV. Three consecutive traces of EPSCs are shown in an expanded scale in time, before (bottom left) and under the action of LTB4 (bottom right). LTB4 slightly enhanced the amplitude of NMDA receptor-mediated sEPSCs in spinal dorsal horn neurons of SNI model rats. b, c Bar graphs showing the average frequency and amplitude of NMDA receptor-mediated sEPSC under the treatment with LTB4 (black bar), relative to those before this treatment (control, open bar) in naïve (b) and SNI model rats (c) (naïve; n = 5. SNI; n = 5). Statistical significance between data shown by bars is indicated by an asterisk; *, P < 0.05; n.s., not significant

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Molecular Pain

ISSN: 1744-8069

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